Dustin Edwards

Palmitoylation and p8-Mediated Human T-Cell Leukemia Virus Type 1 Transmission

Dustin Edwards, Risaku Fukumoto, Maria Fernanda de Castro-Amarante, Luiz Carlos Junior Alcantara, Bernardo Galvão-Castro, Robyn Washington Parks, Cynthia Pise-Masison, Genoveffa Franchini

2014publishedJournal of Virologyvolume 88, issue 4, pages 2319-232210.1128/jvi.03444-13doiopen accesslicense

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Cited by 12 OpenAlex, read 2026-10-01

Mutating cysteine 39 stops HTLV-1 p8 and p12 from dimerizing and being palmitoylated, but p8 still reaches the cell surface and spreads the virus.

Abstract

The orf-I gene of human T-cell leukemia type 1 (HTLV-1) encodes p8 and p12 and has a conserved cysteine at position 39. p8 and p12 form disulfide-linked dimers, and only the monomeric forms of p8 and p12 are palmitoylated. Mutation of cysteine 39 to alanine (C39A) abrogated dimerization and palmitoylation of both proteins. However, the ability of p8 to localize to the cell surface and to increase cell adhesion and viral transmission was not affected by the C39A mutation.

Cited by 12

OpenAlex, read 2026-09-12. Newest first.

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  2. HTLV-1 p12 is cleaved to p8 by the signal peptidase complex and its inhibition impairs p8-dependent transmission, PLoS Pathogens, 2025
  3. BURNS INDUCE ALTERATIONS IN THE ACYL PROTEOME OF MICE AND HUMANS, Shock, 2024
  4. Transfer of HTLV-1 p8 and Gag to target T-cells depends on VASP, a novel interaction partner of p8, PLoS Pathogens, 2020
  5. Role of HTLV-1 orf-I encoded proteins in viral transmission and persistence, Retrovirology, 2019
  6. Non-Structural Proteins from Human T-cell Leukemia Virus Type 1 in Cellular Membranes—Mechanisms for Viral Survivability and Proliferation, International Journal of Molecular Sciences, 2018
  7. Quantitating the Transfer of the HTLV-1 p8 Protein Between T-Cells by Flow Cytometry, Frontiers in Microbiology, 2018
  8. An “All-In-One” Pharmacophoric Architecture for the Discovery of Potential Broad-Spectrum Anti-Flavivirus Drugs, Applied Biochemistry and Biotechnology, 2018
  9. Human T-Cell Leukemia Virus Type 1 Infection and Adult T-Cell Leukemia, Advances in experimental medicine and biology, 2017
  10. First report of HTLV-1 truncated p12 protein in Brazil, Virulence, 2016
  11. Molecular Mechanisms of HTLV-1 Cell-to-Cell Transmission, Viruses, 2016
  12. Co-dependence of HTLV-1 p12 and p8 Functions in Virus Persistence, PLoS Pathogens, 2014

Human and simian retroviruses